Box girder bridges are becoming more common because of their ease of construction, pleasing aesthetics, and serviceability. Projects with curved configuration and long spans can especially benefit from these advantages. However, the industry lacks a wide range of research on multi-span steel box girder cross-sections and their response to fire events. In addition, steel box girders are commonly constructed from weathering steel, which has little available research into their performance in fire. This paper will discuss the current literature, challenges, and available verification studies for this particular combination of cross section and material properties.